Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality\nworldwide. In an attempt to understand some potential mechanisms of persistence and oncogenicity\nof Hepatitis C virus (HCV)-related HCC, microfibrillar-associated protein 4 (MFAP4), fibrotic indices\nand oxidative status biomarkers were assessed in the sera of 50 patients with HCV-associated HCC,\n25 patients with HCV-related liver cirrhosis and 15 healthy individuals. Serum oxidized Coenzyme\nQ10 (CoQ10) and malondialdehyde showed significant elevation in HCC patients compared to the\ncontrol group ..... as well as cirrhotic patients .... while serum\nglutathione content and superoxide dismutase activity were significantly decreased in HCC patients\ncompared to the control group ....... Serum MFAP4, aspartate aminotransferase to platelet\nratio index (APRI), fibrosis index based on the 4 factors (FIB-4) and Forns index showed significant\nincrease in HCC patients compared to the control group ...... while only APRI and FIB-4 were\nsignificantly different between HCC and cirrhotic patients ... with a sensitivity of 86% and\n92%, respectively, at cut off... for APRI and .... for FIB-4. Therefore, increasing oxidative stress\nand fibrosis might mediate HCV induced cirrhosis and HCC. APRI and FIB-4 may be used as a simple\nnon-expensive formula for the screening of HCC rather than MFAP4.
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